Women and men share most of the same risk factors for cardiovascular disease, global study finds

Women and men share most of the same risk factors for cardiovascular disease (CVD), according to a large international study – the first study of its kind to include people not only from high-income countries, but also from low-income countries low and intermediate where the burden of cardiovascular disease is highest.

The study was published today in The Lancet.

The global study assessed risk factors, including metabolic (such as high blood pressure, obesity and diabetes), behavioral (smoking and diet) and psychosocial (economic status and depression) in around 156,000 people no history of CVD aged 35 years. and 70. Living in 21 low-, middle- and high-income countries on five continents, they were followed for an average of 10 years.

Women and men have similar CVD risk factors, highlighting the importance of a similar strategy for preventing CVD in men and women.”

Marjan Walli-Attaei, first author of the article, researcher at the Population Health Research Institute (PHRI) of McMaster University and Hamilton Health Sciences (HHS)

Overall, women had a lower risk of developing CVD than men, especially at a younger age.

However, diet was more strongly associated with CVD risk in women than in men – “something that hasn’t been described before and requires independent confirmation,” said lead researcher Salim Yusuf. study, lead author, executive director of PHRI, professor of medicine at McMaster University and cardiologist at HHS.

High levels of bad cholesterol (LDL) and symptoms of depression were more strongly associated with CVD risk in men than in women.

Patterns of these outcomes were generally similar in high-income and upper-middle-income countries, and in low- and lower-middle-income countries.

Funding was provided by PHRI, Hamilton Health Sciences Research Institute, Canadian Institutes of Health Research (including through the Strategy for Patient-Oriented Research through of the Ontario SPOR Support Unit), the Ontario Division of the Heart and Stroke Foundation and the Ontario Ministry of Health and Long-Term Care.


Journal reference:

Walli-Attaei, M., et al. (2022) Metabolic, behavioral and psychosocial risk factors and cardiovascular disease in women compared to men in 21 high-, middle- and low-income countries: an analysis of the PURE study. The Lancet. doi.org/10.1016/S0140-6736(22)01441-6.

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